Stress-Induced Behavioral Quiescence and Abnormal Rest-Activity Rhythms During Critical Illness.

ABSTRACT:

Objectives

To characterize acute alterations of circadian and ultradian rest-activity rhythms in critically ill patients and their association with brain dysfunction, systemic multiple organ dysfunction, and melatonin rhythms.

Design

Prospective study observing a cohort for 48 hours beginning within the first day of ICU admission.

Setting

ICUs within an academic medical center.

Patients

Patients presenting from the community with acute onset of either intracerebral hemorrhage or sepsis as representative neurologic and systemic critical illnesses. Healthy control patients were studied in the community, during hospital bedrest, and during sleep deprivation.

Interventions

None.

Measurements and main results

Circadian and ultradian characteristics of

SUBMITTER: Maas MB 

PROVIDER: S-EPMC7242144 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature