Disrupted Rest-Activity Rhythms and Cerebral Small Vessel Disease Pathology in Older Adults.

ABSTRACT:

Background and purpose

The pathogenesis of cerebral small vessel disease remains incompletely understood. The relationship between circadian rhythm disturbances and histopathologic measures of cerebral small vessel disease has not been studied. We hypothesized that disrupted circadian rest-activity rhythms would be associated with a higher burden of cerebral small vessel disease pathology.

Methods

We studied 561 community-dwelling older adults (mean age at death, 91.2, 27.4% male) from the Rush Memory and Aging Project. We used actigraphy to quantify several measures of 24-hour rest-activity rhythmicity, including interdaily stability, intradaily variability, and amplitude, and used ordinal logistic regression models to relate these measures to the severity of cerebral arter

SUBMITTER: Sommer R 

PROVIDER: S-EPMC8790726 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature