Ontology highlight
ABSTRACT:
SUBMITTER: Widera P
PROVIDER: S-EPMC7242357 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Widera Paweł P Welsing Paco M J PMJ Ladel Christoph C Loughlin John J Lafeber Floris P F J FPFJ Petit Dop Florence F Larkin Jonathan J Weinans Harrie H Mobasheri Ali A Bacardit Jaume J
Scientific reports 20200521 1
Conventional inclusion criteria used in osteoarthritis clinical trials are not very effective in selecting patients who would benefit from a therapy being tested. Typically majority of selected patients show no or limited disease progression during a trial period. As a consequence, the effect of the tested treatment cannot be observed, and the efforts and resources invested in running the trial are not rewarded. This could be avoided, if selection criteria were more predictive of the future dise ...[more]