NOD2 modulates immune tolerance via the GM-CSF-dependent generation of CD103⁺ dendritic cells.

ABSTRACT: Four decades ago, it was identified that muramyl dipeptide (MDP), a peptidoglycan-derived bacterial cell wall component, could display immunosuppressive functions in animals through mechanisms that remain unexplored. We sought to revisit these pioneering observations because mutations in NOD2, the gene encoding the host sensor of MDP, are associated with increased risk of developing the inflammatory bowel disease Crohn's disease, thus suggesting that the loss of the immunomodulatory functions of NOD2 could contribute to the development of inflammatory disease. Here, we demonstrate that intraperitoneal (i.p.) administration of MDP triggered regulatory T cells and the accumulation of a population of tolerogenic CD103⁺ dendritic cells (DCs) in the spleen. This was found to o

SUBMITTER: Prescott D 

PROVIDER: S-EPMC7245098 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature