Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.

ABSTRACT:

Objectives

The beneficial effects of a physically active lifestyle in aging are well documented. Understanding the factors of importance for physical activity in older adults are therefore essential. Informed by animal and human data linking the dopamine system to motivation and reward processes, we investigated the associations between variations in dopamine genes and objectively measured physical activity and sedentary behaviour. Further, we aimed to verify whether higher age may exacerbate the impact of dopamine genes on physical activity.

Methods

We analyzed data from 504 older adults, 66-87 years, from the population-based Swedish National study on Aging and Care in Kungsholmen (SNAC-K). Physical activity was measured with activPAL accelerometers and DNA was extracted f

SUBMITTER: Dohrn IM 

PROVIDER: S-EPMC7245799 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature