Ontology highlight
ABSTRACT:
SUBMITTER: Ragotte RJ
PROVIDER: S-EPMC7246332 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Ragotte Robert J RJ Higgins Matthew K MK Draper Simon J SJ
Trends in parasitology 20200428 6
Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the most advanced to date, affording moderate levels of efficacy in field trials. However, the discovery that the members of the merozoite PfRH5-PfCyRPA-PfRipr (RCR) complex are capable of inducing strain-transcendent neutralizing antibodies has renewed enthusiasm for the possibility of preventing disease by targetin ...[more]