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The RH5-CyRPA-Ripr Complex as a Malaria Vaccine Target.


ABSTRACT: Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the most advanced to date, affording moderate levels of efficacy in field trials. However, the discovery that the members of the merozoite PfRH5-PfCyRPA-PfRipr (RCR) complex are capable of inducing strain-transcendent neutralizing antibodies has renewed enthusiasm for the possibility of preventing disease by targeting the parasite during the blood stage of infection. With Phase I/II clinical trials now underway using first-generation vaccines against PfRH5, and more on the horizon for PfCyRPA and PfRipr, this review explores the rationale and future potential of the RCR complex as a P. falciparum vaccine target.

SUBMITTER: Ragotte RJ 

PROVIDER: S-EPMC7246332 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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The RH5-CyRPA-Ripr Complex as a Malaria Vaccine Target.

Ragotte Robert J RJ   Higgins Matthew K MK   Draper Simon J SJ  

Trends in parasitology 20200428 6


Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the most advanced to date, affording moderate levels of efficacy in field trials. However, the discovery that the members of the merozoite PfRH5-PfCyRPA-PfRipr (RCR) complex are capable of inducing strain-transcendent neutralizing antibodies has renewed enthusiasm for the possibility of preventing disease by targetin  ...[more]

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