Ontology highlight
ABSTRACT:
SUBMITTER: Sacchetto C
PROVIDER: S-EPMC7246991 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Sacchetto Claudia C Vitiello Libero L de Windt Leon J LJ Rampazzo Alessandra A Calore Martina M
International journal of molecular sciences 20200511 9
In the last decade, the generation of cardiac disease models based on human-induced pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to overcome the lack of appropriate cardiac models. Although much progress has been made toward the generation of hiPSC-derived cardiomyocytes (hiPS-CMs), several lines of evidence indicate that two-dimensional (2D) cell culturing presents significant limitations, including hiPS-CMs immaturity and the absence of interaction betw ...[more]