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Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.

ABSTRACT: The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120?h after death, expanding the availability and use of human diseased tissue stored in brain banks.

SUBMITTER: Scaduto P 

PROVIDER: S-EPMC7248056 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.

Scaduto Pietro P   Sequeira Adolfo A   Vawter Marquis P MP   Bunney William W   Limon Agenor A  

Scientific reports 20200525 1

The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks. ...[more]

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