Ontology highlight
ABSTRACT:
SUBMITTER: Perez LG
PROVIDER: S-EPMC7248087 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Perez Laura Garcia LG Kempski Jan J McGee Heather M HM Pelzcar Penelope P Agalioti Theodora T Giannou Anastasios A Konczalla Leonie L Brockmann Leonie L Wahib Ramez R Xu Hao H Vesely Maria Carolina Amezcua MCA Soukou Shiwa S Steglich Babett B Bedke Tanja T Manthey Carolin C Seiz Oliver O Diercks Björn-Philipp BP Gnafakis Stylianos S Guse Andreas H AH Perez Daniel D Izbicki Jakob R JR Gagliani Nicola N Flavell Richard A RA Huber Samuel S
Nature communications 20200525 1
IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cance ...[more]