Ontology highlight
ABSTRACT:
SUBMITTER: Festa A
PROVIDER: S-EPMC7248176 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Festa Adalgisa A Umano Giuseppina Rosaria GR Miraglia Del Giudice Emanuele E Grandone Anna A
Frontiers in endocrinology 20200519
Delayed puberty is a common reason of pediatric endocrinological consultation. It is often a self-limited (or constitutional) condition with a strong familial basis. The type of inheritance is variable but most commonly autosomal dominant. Despite this strong genetic determinant, mutations in genes implicated in the regulation of hypothalamic-pituitary-gonadal axis have rarely been identified in cases of self-limited delayed puberty and often in relatives of patients with congenital hypogonadotr ...[more]