Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion.
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ABSTRACT:
SUBMITTER: Ha VL
PROVIDER: S-EPMC7249260 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion.
Ha Vi Luan VL Luo Ruibai R Nie Zhongzhen Z Randazzo Paul A PA
Advances in cancer research 20080101
Arf GAPs are a family of proteins with a common catalytic domain that induces hydrolysis of GTP bound to the small GTP-binding protein Arf. The proteins are otherwise structurally diverse. Several subtypes of Arf GAPs have been found to be targets of oncogenes and to control cell proliferation and cell migration. The latter effects are thought to be mediated by coordinating changes in actin remodeling and membrane traffic. In this chapter, we discuss Arf GAPs that have been linked to oncogenesis ...[more]
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