Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC7250575 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Guo Yajuan Y Redmond Catherine J CJ Leacock Krystynne A KA Brovkina Margarita V MV Ji Suyun S Jaskula-Ranga Vinod V Coulombe Pierre A PA
eLife 20200505
The intermediate filament protein keratin 14 (K14) provides vital structural support in basal keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and dynamics of keratin IFs in skin keratinocytes. Here we report that knock-in mice harboring a cysteine-to-alanine substitution at <i>Krt14</i>'s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit ...[more]