Progression-free survival as a surrogate for overall survival in oncology trials: a methodological systematic review.

ABSTRACT:

Background

Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describe their methodological characteristics.

Methods

We conducted a systematic review by searching MEDLINE via PubMed and the Cochrane Library with no limitation on time, selected relevant studies and extracted data in duplicate on how surrogacy was evaluated (meta-analytic approach, assessment of correlation and level of evaluation).

Results

We identified 91 studies evaluating the validity of PFS as a surrogate for OS in 24 cancer localisations. Although a m

SUBMITTER: Belin L 

PROVIDER: S-EPMC7250908 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature