Ontology highlight
ABSTRACT:
SUBMITTER: Vogel JW
PROVIDER: S-EPMC7251068 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Vogel Jacob W JW Iturria-Medina Yasser Y Strandberg Olof T OT Smith Ruben R Levitis Elizabeth E Evans Alan C AC Hansson Oskar O
Nature communications 20200526 1
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer's disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our mod ...[more]