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Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities.

ABSTRACT: Blood oxygen saturation (SaO2) is one of the most important environmental factors in clinical heart protection. This study used human heart samples and human induced pluripotent stem cell-cardiomyocytes (iPSC-CMs) to assess how SaO2 affects human CM cell cycle activities. The results showed that there were significantly more cell cycle markers in the moderate hypoxia group (SaO2: 75% to 85%) than in the other 2 groups (SaO2 <75% or >85%). In iPSC-CMs 15% and 10% oxygen (O2) treatment increased cell cycle markers, whereas 5% and rapid change of O2 decreased the markers. Moderate hypoxia is beneficial to the cell cycle activities of post-natal human CMs.

SUBMITTER: Ye L

PROVIDER: S-EPMC7251192 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities.

Ye Lincai L Qiu Lisheng L Feng Bei B Jiang Chuan C Huang Yanhui Y Zhang Haibo H Zhang Hao H Hong Haifa H Liu Jinfen J

JACC. Basic to translational science 20200422 5

Blood oxygen saturation (SaO2) is one of the most important environmental factors in clinical heart protection. This study used human heart samples and human induced pluripotent stem cell-cardiomyocytes (iPSC-CMs) to assess how SaO2 affects human CM cell cycle activities. The results showed that there were significantly more cell cycle markers in the moderate hypoxia group (SaO2: 75% to 85%) than in the other 2 groups (SaO2 <75% or >85%). In iPSC-CMs 1 ...[more]

PMID: 32478207

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