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Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8.

ABSTRACT: Resistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism. However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation. In this study, we found that resistin upregulated expression of the p65 subunit of NF-?B, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells.

SUBMITTER: Wen F

PROVIDER: S-EPMC7251471 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8.

Wen Fengyun F Xia Qiao Q Zhang Hui H Shia Haipeng H Rajesh Amin A Wu Yanling Y Yang Yi Y Yang Zaiqing Z

International journal of endocrinology 20200518

Resistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism. However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellula ...[more]

PMID: 32508919

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