Ontology highlight
ABSTRACT:
SUBMITTER: Collins MK
PROVIDER: S-EPMC7253030 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Collins Morgan K MK Shotland Abigail M AM Wade Morgan F MF Atif Shaikh M SM Richards Denay K DK Torres-Llompart Manolo M Mack Douglas G DG Martin Allison K AK Fontenot Andrew P AP McKee Amy S AS
JCI insight 20200507 9
Chronic beryllium disease (CBD) is a metal hypersensitivity/autoimmune disease in which damage-associated molecular patterns (DAMPs) promote a break in T cell tolerance and expansion of Be2+/self-peptide-reactive CD4+ T cells. In this study, we investigated the mechanism of cell death induced by beryllium particles in alveolar macrophages (AMs) and its impact on DAMP release. We found that phagocytosis of Be led to AM cell death independent of caspase, receptor-interacting protein kinases 1 and ...[more]