Ontology highlight
ABSTRACT:
SUBMITTER: Schwein PA
PROVIDER: S-EPMC7253032 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
ACS chemical biology 20200310 3
O-Linked N-acetyl glucosamine (O-GlcNAc) is a protein modification found on thousands of nuclear, cytosolic, and mitochondrial proteins. Many O-GlcNAc sites occur in proximity to protein sites that are likewise modified by phosphorylation. While several studies have uncovered crosstalk between these two signaling modifications on individual proteins and pathways, an understanding of the role of O-GlcNAc in regulating kinases, the enzymes that install the phosphate modification, is still emerging ...[more]