Ontology highlight
ABSTRACT:
SUBMITTER: Aulak KS
PROVIDER: S-EPMC7334407 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Aulak Kulwant S KS Barnes Jarrod W JW Tian Liping L Mellor Noel E NE Haque Mohammad M MM Willard Belinda B Li Ling L Comhair Suzy C SC Stuehr Dennis J DJ Dweik Raed A RA
Redox biology 20200627
Idiopathic pulmonary arterial hypertension (IPAH) is a progressive and devastating disease characterized by vascular smooth muscle and endothelial cell proliferation leading to a narrowing of the vessels in the lung. The increased resistance in the lung and the higher pressures generated result in right heart failure. Nitric Oxide (NO) deficiency is considered a hallmark of IPAH and altered function of endothelial nitric oxide synthase (eNOS), decreases NO production. We recently demonstrated th ...[more]