Ontology highlight
ABSTRACT:
SUBMITTER: Lock JT
PROVIDER: S-EPMC7253181 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
eLife 20200512
The 'building-block' model of inositol trisphosphate (IP<sub>3</sub>)-mediated Ca<sup>2+</sup> liberation posits that cell-wide cytosolic Ca<sup>2+</sup> signals arise through coordinated activation of localized Ca<sup>2+</sup> puffs generated by stationary clusters of IP<sub>3</sub> receptors (IP<sub>3</sub>Rs). Here, we revise this hypothesis, applying fluctuation analysis to resolve Ca<sup>2+</sup> signals otherwise obscured during large Ca<sup>2+</sup> elevations. We find the rising phase of ...[more]