Si-Fe-C-N Coatings for Biomedical Applications: A Combinatorial Approach.

ABSTRACT: Ceramic coatings may prolong the lifetime of joint implants. Certain ions and wear debris may however lead to negative biological effects. SiN-based materials may substantially reduce these effects, but still need optimization for the application. In this study, a combinatorial deposition method enabled an efficient evaluation of a range of Si-Fe-C-N coating compositions on the same sample. The results revealed compositional gradients of Si (26.0-33.9 at.%), Fe (9.6-20.9 at.%), C (8.2-13.9 at.%) and N (39.7-47.2 at.%), and low oxygen contaminations (0.3-0.6 at.%). The mechanical properties varied with a hardness (H) ranging between 13.7-17.3 GPa and an indentation modulus (M) between 190-212 GPa. Both H and M correlated with the Si (H and M increased as Si increased) and Fe (H and M decreased as Fe increased) content. A slightly columnar morphology was observed in cross-sections, as well as a surface roughness in the nm range. A cell study revealed adhering pre-osteogenic MC3T3 cells, with a morphology similar to that of cells seeded on a tissue culture plastic control. The investigated coatings could be considered for further investigation due to the ability to tune their mechanical properties while maintaining a smooth surface, together with their promising in vitro cell response.

SUBMITTER: Skjoldebrand C 

PROVIDER: S-EPMC7254256 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature