Meningitis, urinary tract, and bloodstream infections in very low birth weight infants enrolled in a heart rate characteristics monitoring trial.

ABSTRACT: BACKGROUND:Displaying heart rate characteristic (HRC) scores was associated with lower sepsis-associated mortality in very low birth weight (VLBW) infants in a multicenter randomized controlled trial (HeRO trial). The aim of this study was to test whether HRC indices rise before diagnosis of urinary tract infection (UTI) or meningitis, with and without concomitant BSI. METHODS:Blood, urine, and cerebrospinal fluid (CSF) culture data after 3 days of age and within 120 days of study enrollment were analyzed from 2989 VLBW infants. The HRC index was analyzed 12?h prior to positive cultures compared to 36?h prior, using paired signed-rank tests. RESULTS:UTI, meningitis, and BSI were diagnosed in 10%, 2%, and 24% of infants, respectively. The mean hourly HRC index was significantly higher 12?h prior to diagnosis of UTI and BSI compared to 36?h prior (UTI 2.07 versus 1.81; BSI 2.62 versus 2.25, both p?

SUBMITTER: Weitkamp JH 

PROVIDER: S-EPMC7255929 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature