Coding Polymorphisms in Zinc Transporter Gene SLC39A12 (ZIP12) Associated with Brain MRI Pattern Differences Have Reduced Zinc Transport Activity

ABSTRACT: Abstract

Objectives

Zinc is important for brain function. The SLC39A12 gene encodes ZIP12, which is a zinc transport protein highly expressed in the brain. Our goal is to determine whether human slc39a12 coding polymorphisms associated with differences in susceptibility-weighted brain MRI (swMRI) patterns affect zinc transport ability.

Methods

We used summary statistics for a genome-wide association study (GWAS) on swMRI patterns for caudate, putamen, and pallidum of 7778 human subjects aged 40–69 years from the UK BioBank. Human SLC39A12 coding polymorphisms rs10764176 and rs72778328 were associated with a reduction in relaxation spin time during swMRI in the putamen or pallidum but not caudate and met a significance cutoff of P < 5.0 × 10–8. Haploblock determination and

SUBMITTER: Chambers E 

PROVIDER: S-EPMC7259093 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature