Ontology highlight
ABSTRACT:
SUBMITTER: Hidalgo-Sastre A
PROVIDER: S-EPMC7259520 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Hidalgo-Sastre Ana A Desztics Judit J Dantes Zahra Z Schulte Katharina K Ensarioglu Hilal Kabadayi HK Bassey-Archibong Blessing B Öllinger Rupert R Engleiter Thomas T Rayner Lyndsay L Einwächter Henrik H Daniel Juliet M JM Altaee Ali Sameer Abdulghani ASA Steiger Katia K Lesina Marina M Rad Roland R Reichert Maximilian M von Figura Guido G Siveke Jens T JT Schmid Roland M RM Lubeseder-Martellato Clara C
JCI insight 20200521 10
Several studies have suggested an oncogenic role for the neural Wiskott-Aldrich syndrome protein (N-WASP, encoded by the Wasl gene), but thus far, little is known about its function in pancreatic ductal adenocarcinoma (PDAC). In this study, we performed in silico analysis of WASL expression in PDAC patients and found a correlation between low WASL expression and prolonged survival. To clarify the role of Wasl in pancreatic carcinogenesis, we used 2 oncogenic Kras-based PDAC mouse models with pan ...[more]