Ontology highlight
ABSTRACT:
SUBMITTER: Sayama S
PROVIDER: S-EPMC7259528 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Sayama Seisuke S Song Anren A Brown Benjamin C BC Couturier Jacob J Cai Xiaoli X Xu Ping P Chen Changhan C Zheng Yangxi Y Iriyama Takayuki T Sibai Baha B Longo Monica M Kellems Rodney E RE D'Alessandro Angelo A Xia Yang Y
JCI insight 20200521 10
Insufficient O2 supply is frequently associated with fetal growth restriction (FGR), a leading cause of perinatal mortality and morbidity. Although the erythrocyte is the most abundant and only cell type to deliver O2 in our body, its function and regulatory mechanism in FGR remain unknown. Here, we report that genetic ablation of mouse erythrocyte equilibrative nucleoside transporter 1 (eENT1) in dams, but not placentas or fetuses, results in FGR. Unbiased high-throughput metabolic profiling co ...[more]