Ontology highlight
ABSTRACT:
SUBMITTER: Podolsky MJ
PROVIDER: S-EPMC7259530 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Podolsky Michael J MJ Yang Christopher D CD Valenzuela Carlos Lizama CL Datta Ritwik R Huang Steven K SK Nishimura Stephen L SL Dallas Sarah L SL Wolters Paul J PJ Le Saux Claude Jourdan CJ Atabai Kamran K
JCI insight 20200521 10
Although aging represents the most important epidemiologic risk factor for fibrotic disease, the reasons for this are incompletely understood. Excess collagen deposition in tissues is the sine qua non of tissue fibrosis and can be viewed as an imbalance between collagen production and collagen degradation. Yet we still lack a detailed understanding of the changes that take place during development, maturation, and aging in extracellular matrix (ECM) dynamics. Resolution of fibrosis is impaired i ...[more]