Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve.
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ABSTRACT:
SUBMITTER: Canclini L
PROVIDER: S-EPMC7259579 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve.
Canclini Lucía L Farias Joaquina J Di Paolo Andrés A Sotelo-Silveira José R JR Folle Gustavo G Kun Alejandra A Sotelo José R JR
PloS one 20200529 5
Transference of RNAs and ribosomes from Schwann cell-to-axon was demonstrated in normal and regenerating peripheral nerves. Previously, we have shown that RNAs transfer is dependent on F-actin cytoskeleton and Myosin Va. Here, we explored the contribution of microtubules to newly synthesized RNAs transport from Schwann cell nuclei up to nodal microvilli in sciatic nerves. Results using immunohistochemistry and quantitative confocal FRET analysis indicate that Schwann cell-derived RNAs co-localiz ...[more]
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