Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC7695724 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Feng Xiaona X Takayama Yasunori Y Ohno Nobuhiko N Kanda Hirosato H Dai Yi Y Sokabe Takaaki T Tominaga Makoto M
Communications biology 20201127 1
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective calcium-permeable cation channel that is widely expressed and activated in various neurons and glial cells in the nervous system. Schwann cells (SCs) are primary glia cells that wrap around axons to form the myelin sheath in the peripheral nervous system. However, whether TRPV4 is expressed and functions in SCs is unclear. Here, we demonstrate functional expression of TRPV4 in mouse SCs and investigated its physiological signifi ...[more]