On the Interpretability of Artificial Intelligence in Radiology: Challenges and Opportunities.
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ABSTRACT:
SUBMITTER: Reyes M
PROVIDER: S-EPMC7259808 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:ObjectivesThe aim is to offer an overview of the existing training programs and critically examine them and suggest avenues for further development of AI training programs for radiologists.MethodsDeductive thematic analysis of 100 training programs offered in 2019 and 2020 (until June 30). We analyze the public data about the training programs based on their "contents," "target audience," "instructors and offering agents," and "legitimization strategies."ResultsThere are many AI training programs offered to radiologists, yet most of them (80%) are short, stand-alone sessions, which are not part of a longer-term learning trajectory. The training programs mainly (around 85%) focus on the basic concepts of AI and are offered in passive mode. Professional institutions and commercial companies are active in offering the programs (91%), though academic institutes are limitedly involved.ConclusionsThere is a need to further develop systematic training programs that are pedagogically integrated into radiology curriculum. Future training programs need to further focus on learning how to work with AI at work and be further specialized and customized to the contexts of radiology work.Key points• Most of AI training programs are short, stand-alone sessions, which focus on the basics of AI. • The content of training programs focuses on medical and technical topics; managerial, legal, and ethical topics are marginally addressed. • Professional institutions and commercial companies are active in offering AI training; academic institutes are limitedly involved.
| S-EPMC8270863 | biostudies-literature
Project description:The interest in artificial intelligence (AI) has ballooned within radiology in the past few years primarily due to notable successes of deep learning. With the advances brought by deep learning, AI has the potential to recognize and localize complex patterns from different radiological imaging modalities, many of which even achieve comparable performance to human decision-making in recent applications. In this chapter, we review several AI applications in radiology for different anatomies: chest, abdomen, pelvis, as well as general lesion detection/identification that is not limited to specific anatomies. For each anatomy site, we focus on introducing the tasks of detection, segmentation, and classification with an emphasis on describing the technology development pathway with the aim of providing the reader with an understanding of what AI can do in radiology and what still needs to be done for AI to better fit in radiology. Combining with our own research experience of AI in medicine, we elaborate how AI can enrich knowledge discovery, understanding, and decision-making in radiology, rather than replacing the radiologist.
| S-EPMC7484814 | biostudies-literature
Project description:Clustered regularly interspaced short palindromic repeat (CRISPR)-based genome editing (GED) technologies have unlocked exciting possibilities for understanding genes and improving medical treatments. On the other hand, Artificial intelligence (AI) helps genome editing achieve more precision, efficiency, and affordability in tackling various diseases, like Sickle cell anemia or Thalassemia. AI models have been in use for designing guide RNAs (gRNAs) for CRISPR-Cas systems. Tools like DeepCRISPR, CRISTA, and DeepHF have the capability to predict optimal guide RNAs (gRNAs) for a specified target sequence. These predictions take into account multiple factors, including genomic context, Cas protein type, desired mutation type, on-target/off-target scores, potential off-target sites, and the potential impacts of genome editing on gene function and cell phenotype. These models aid in optimizing different genome editing technologies, such as base, prime, and epigenome editing, which are advanced techniques to introduce precise and programmable changes to DNA sequences without relying on the homology-directed repair pathway or donor DNA templates. Furthermore, AI, in collaboration with genome editing and precision medicine, enables personalized treatments based on genetic profiles. AI analyzes patients' genomic data to identify mutations, variations, and biomarkers associated with different diseases like Cancer, Diabetes, Alzheimer's, etc. However, several challenges persist, including high costs, off-target editing, suitable delivery methods for CRISPR cargoes, improving editing efficiency, and ensuring safety in clinical applications. This review explores AI's contribution to improving CRISPR-based genome editing technologies and addresses existing challenges. It also discusses potential areas for future research in AI-driven CRISPR-based genome editing technologies. The integration of AI and genome editing opens up new possibilities for genetics, biomedicine, and healthcare, with significant implications for human health.
| S-EPMC10800897 | biostudies-literature
Project description:As Artificial Intelligence (AI) proliferates across important social institutions, many of the most powerful AI systems available are difficult to interpret for end-users and engineers alike. Here, we sought to characterize public attitudes towards AI interpretability. Across seven studies (N = 2475), we demonstrate robust and positive attitudes towards interpretable AI among non-experts that generalize across a variety of real-world applications and follow predictable patterns. Participants value interpretability positively across different levels of AI autonomy and accuracy, and rate interpretability as more important for AI decisions involving high stakes and scarce resources. Crucially, when AI interpretability trades off against AI accuracy, participants prioritize accuracy over interpretability under the same conditions driving positive attitudes towards interpretability in the first place: amidst high stakes and scarce resources. These attitudes could drive a proliferation of AI systems making high-impact ethical decisions that are difficult to explain and understand. For many AI systems, it is hard to interpret how they make decisions. Here, the authors show that non-experts value interpretability in AI, especially for decisions involving high stakes and scarce resources, but they sacrifice AI interpretability when it trades off against AI accuracy.
| S-EPMC9528860 | biostudies-literature
Project description:The evidence-based medicine (EBM) movement is stepping up its efforts to assess medical artificial intelligence (AI) and data science studies. Since 2017, there has been a marked increase in the number of published systematic reviews that assess medical AI studies. Increasingly, data from observational studies are used in systematic reviews of medical AI studies. Assessment of risk of bias is especially important in medical AI studies to detect possible "AI bias".
| S-EPMC9238033 | biostudies-literature
Project description:Recently, there has been great interest in developing Artificial Intelligence (AI) enabled computer-aided diagnostics solutions for the diagnosis of skin cancer. With the increasing incidence of skin cancers, low awareness among a growing population, and a lack of adequate clinical expertise and services, there is an immediate need for AI systems to assist clinicians in this domain. A large number of skin lesion datasets are available publicly, and researchers have developed AI solutions, particularly deep learning algorithms, to distinguish malignant skin lesions from benign lesions in different image modalities such as dermoscopic, clinical, and histopathology images. Despite the various claims of AI systems achieving higher accuracy than dermatologists in the classification of different skin lesions, these AI systems are still in the very early stages of clinical application in terms of being ready to aid clinicians in the diagnosis of skin cancers. In this review, we discuss advancements in the digital image-based AI solutions for the diagnosis of skin cancer, along with some challenges and future opportunities to improve these AI systems to support dermatologists and enhance their ability to diagnose skin cancer.
| S-EPMC8290363 | biostudies-literature
Project description:Artificial metalloenzymes (ArMs) result from the incorporation of an abiotic metal cofactor within a protein scaffold. From the earliest techniques of transition metals adsorbed on silk fibers, the field of ArMs has expanded dramatically over the past 60 years to encompass a range of reaction classes and inspired approaches: Assembly of the ArMs has taken multiple forms with both covalent and supramolecular anchoring strategies, while the scaffolds have been intuitively selected and evolved, repurposed, or designed in silico. Herein, we discuss some of the most prominent recent examples of ArMs to highlight the challenges and opportunities presented by the field.
| S-EPMC6661864 | biostudies-literature
Project description:Artificial intelligence (AI) is here to stay and will change health care as we know it. The availability of big data and the increasing numbers of AI algorithms approved by the US Food and Drug Administration together will help in improving the quality of care for patients and in overcoming human fatigue barriers. In oncology practice, patients and providers rely on the interpretation of radiologists when making clinical decisions; however, there is considerable variability among readers, and in particular for prostate imaging. AI represents an emerging solution to this problem, for which it can provide a much-needed form of standardization. The diagnostic performance of AI alone in comparison to a combination of an AI framework and radiologist assessment for evaluation of prostate imaging has yet to be explored. Here, we compare the performance of radiologists alone versus a combination of radiologists aided by a modern computer-aided diagnosis (CAD) AI system. We show that the radiologist-CAD combination demonstrates superior sensitivity and specificity in comparison to both radiologists alone and AI alone. Our findings demonstrate that a radiologist + AI combination could perform best for detection of prostate cancer lesions. A hybrid technology-human system could leverage the benefits of AI in improving radiologist performance while also reducing physician workload, minimizing burnout, and enhancing the quality of patient care.Patient summaryOur report demonstrates the potential of artificial intelligence (AI) for improving the interpretation of prostate scans. A combination of AI and evaluation by a radiologist has the best performance in determining the severity of prostate cancer. A hybrid system that uses both AI and radiologists could maximize the quality of care for patients while reducing physician workload and burnout.
| S-EPMC9794880 | biostudies-literature
Project description:The successful use of artificial intelligence (AI) for diagnostic purposes has prompted the application of AI-based cancer imaging analysis to address other, more complex, clinical needs. In this Perspective, we discuss the next generation of challenges in clinical decision-making that AI tools can solve using radiology images, such as prognostication of outcome across multiple cancers, prediction of response to various treatment modalities, discrimination of benign treatment confounders from true progression, identification of unusual response patterns and prediction of the mutational and molecular profile of tumours. We describe the evolution of and opportunities for AI in oncology imaging, focusing on hand-crafted radiomic approaches and deep learning-derived representations, with examples of their application for decision support. We also address the challenges faced on the path to clinical adoption, including data curation and annotation, interpretability, and regulatory and reimbursement issues. We hope to demystify AI in radiology for clinicians by helping them to understand its limitations and challenges, as well as the opportunities it provides as a decision-support tool in cancer management.
| S-EPMC9034765 | biostudies-literature
Project description:ObjectivesWhy is there a major gap between the promises of AI and its applications in the domain of diagnostic radiology? To answer this question, we systematically review and critically analyze the AI applications in the radiology domain.MethodsWe systematically analyzed these applications based on their focal modality and anatomic region as well as their stage of development, technical infrastructure, and approval.ResultsWe identified 269 AI applications in the diagnostic radiology domain, offered by 99 companies. We show that AI applications are primarily narrow in terms of tasks, modality, and anatomic region. A majority of the available AI functionalities focus on supporting the "perception" and "reasoning" in the radiology workflow.ConclusionsThereby, we contribute by (1) offering a systematic framework for analyzing and mapping the technological developments in the diagnostic radiology domain, (2) providing empirical evidence regarding the landscape of AI applications, and (3) offering insights into the current state of AI applications. Accordingly, we discuss the potential impacts of AI applications on the radiology work and we highlight future possibilities for developing these applications.Key points• Many AI applications are introduced to the radiology domain and their number and diversity grow very fast. • Most of the AI applications are narrow in terms of modality, body part, and pathology. • A lot of applications focus on supporting "perception" and "reasoning" tasks.
| S-EPMC7979626 | biostudies-literature