Ontology highlight
ABSTRACT:
SUBMITTER: Plant T
PROVIDER: S-EPMC7259996 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Plant Tracie T Eamsamarng Suttida S Sanchez-Garcia Manuel A MA Reyes Leila L Renshaw Stephen A SA Coelho Patricia P Mirchandani Ananda S AS Morgan Jessie-May JM Ellett Felix E FE Morrison Tyler T Humphries Duncan D Watts Emily R ER Murphy Fiona F Raffo-Iraolagoitia Ximena L XL Zhang Ailiang A Cash Jenna L JL Loynes Catherine C Elks Philip M PM Van Eeden Freek F Carlin Leo M LM Furley Andrew Jw AJ Whyte Moira Kb MK Walmsley Sarah R SR
The Journal of clinical investigation 20200601 6
Neutrophilic inflammation is central to disease pathogenesis, for example, in chronic obstructive pulmonary disease, yet the mechanisms that retain neutrophils within tissues remain poorly understood. With emerging evidence that axon guidance factors can regulate myeloid recruitment and that neutrophils can regulate expression of a class 3 semaphorin, SEMA3F, we investigated the role of SEMA3F in inflammatory cell retention within inflamed tissues. We observed that neutrophils upregulate SEMA3F ...[more]