Ontology highlight
ABSTRACT:
SUBMITTER: Degano AL
PROVIDER: S-EPMC3290450 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Degano Alicia L AL Pasterkamp R Jeroen RJ Ronnett Gabriele V GV
Molecular and cellular neurosciences 20090721 3
Rett syndrome (RTT) is an autism spectrum disorder that results from mutations in the transcriptional regulator methyl-CpG binding protein 2 (MECP2). In the present work, we demonstrate that MeCP2 deficiency disrupts the establishment of neural connections before synaptogenesis. Using both in vitro and in vivo approaches, we identify dynamic alterations in the expression of class 3 semaphorins that are accompanied by defects in axonal fasciculation, guidance, and targeting with MeCP2 deficiency. ...[more]