Methylation profiling

Dataset Information

0

TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis–induced immune tolerance


ABSTRACT: Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all cause post-infectious morbidity and mortality. We show that TCA cycle also regulates epigenetics, specifically DNA methylation, after infection induced immune tolerance. This data from TB patients who received everolimus with standard of care antibiotics, and have less DNA hypermethylation demonstrating proof of concept that metabolic manipulation can mitigate epigenetic scars.

ORGANISM(S): Homo sapiens

PROVIDER: GSE277003 | GEO | 2024/09/12

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-09-12 | GSE276988 | GEO
| PRJNA945196 | ENA
2013-10-31 | E-GEOD-42830 | biostudies-arrayexpress
2013-10-31 | E-GEOD-42826 | biostudies-arrayexpress
| PRJNA1159897 | ENA
| PRJNA1160204 | ENA
2014-08-01 | E-GEOD-59015 | biostudies-arrayexpress
2016-10-28 | E-MTAB-4257 | biostudies-arrayexpress
2014-08-01 | GSE59015 | GEO
2013-10-31 | GSE42830 | GEO