Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC7261412 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Yuan Yue Y Wei Zhiliang Z Chu Chengyan C Zhang Jia J Song Xiaolei X Walczak Piotr P Bulte Jeff W M JWM
Angewandte Chemie (International ed. in English) 20190917 43
The healthy prostate contains the highest concentration of mobile zinc in the body. As this level decreases dramatically during the initial development of prostate cancer, in vivo detection of prostate zinc content may be applied for diagnosis of prostate cancer. Using <sup>19</sup> F ion chemical exchange saturation transfer magnetic resonance imaging (iCEST MRI) and TF-BAPTA as a fluorinated Zn-binding probe with micromolar sensitivity, we show that iCEST MRI is able to differentiate between n ...[more]