Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions.

ABSTRACT: Cellular senescence refers to a cellular phenotype characterized by an altered transcriptome, pro-inflammatory secretome, and generally irreversible growth arrest. Acutely senescent cells are widely recognized as performing key physiological functions in vivo promoting normal organogenesis, successful wound repair, and cancer defense. In contrast, the accumulation of chronically senescent cells in response to aging, cell stress, genotoxic damage, and other injurious stimuli is increasingly recognized as an important contributor to organ dysfunction, tissue fibrosis, and the more generalized aging phenotype. In this review, we summarize our current knowledge of the role of senescent cells in promoting progressive fibrosis and dysfunction with a particular focus on the kidney and refe

SUBMITTER: Docherty MH 

PROVIDER: S-EPMC7264097 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature