Ontology highlight
ABSTRACT:
SUBMITTER: Eller C
PROVIDER: S-EPMC7264273 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200601 1
Chronic HBV infection is a major cause of liver disease and cancer worldwide. Approaches for cure are lacking, and the knowledge of virus-host interactions is still limited. Here, we perform a genome-wide gain-of-function screen using a poorly permissive hepatoma cell line to uncover host factors enhancing HBV infection. Validation studies in primary human hepatocytes identified CDKN2C as an important host factor for HBV replication. CDKN2C is overexpressed in highly permissive cells and HBV-inf ...[more]