Ontology highlight
ABSTRACT:
SUBMITTER: Petrova E
PROVIDER: S-EPMC6356745 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Petrova Evgeniya E Gracias Ségolène S Beauclair Guillaume G Tangy Frédéric F Jouvenet Nolwenn N
Viruses 20190115 1
Flaviviruses, such as dengue (DENV), West Nile (WNV), yellow fever (YFV) and Zika (ZIKV) viruses, are mosquito-borne pathogens that present a major risk to global public health. To identify host factors that promote flavivirus replication, we performed a genome-wide gain-of-function cDNA screen for human genes that enhance the replication of flavivirus reporter particles in human cells. The screen recovered seventeen potential host proteins that promote viral replication, including the previousl ...[more]