Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC7264355 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Wang Chenwei C Shui Ke K Ma Shanshan S Lin Shaofeng S Zhang Ying Y Wen Bo B Deng Wankun W Xu Haodong H Hu Hui H Guo Anyuan A Xue Yu Y Zhang Luoying L
Nature communications 20200601 1
Most organisms on the earth exhibit circadian rhythms in behavior and physiology, which are driven by endogenous clocks. Phosphorylation plays a central role in timing the clock, but how this contributes to overt rhythms is unclear. Here we conduct phosphoproteomics in conjunction with transcriptomic and proteomic profiling using fly heads. By developing a pipeline for integrating multi-omics data, we identify 789 (~17%) phosphorylation sites with circadian oscillations. We predict 27 potential ...[more]