Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.

Methods

Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).

Results

Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F₂-isoprostane 8-iso-prostaglandin F_2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD

SUBMITTER: Causer AJ 

PROVIDER: S-EPMC7264436 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature