Ontology highlight
ABSTRACT:
SUBMITTER: Scialo F
PROVIDER: S-EPMC7264463 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Scialò Filippo F Sriram Ashwin A Stefanatos Rhoda R Spriggs Ruth V RV Loh Samantha H Y SHY Martins L Miguel LM Sanz Alberto A
Redox biology 20200207
Reactive Oxygen Species (ROS) are essential cellular messengers required for cellular homeostasis and regulate the lifespan of several animal species. The main site of ROS production is the mitochondrion, and within it, respiratory complex I (CI) is the main ROS generator. ROS produced by CI trigger several physiological responses that are essential for the survival of neurons, cardiomyocytes and macrophages. Here, we show that CI produces ROS when electrons flow in either the forward (Forward E ...[more]