Proteomics

Dataset Information

0

Suppression of mitochondrial complex 1 in Drosophila melanogaster


ABSTRACT: Aberrant mitochondrial function has been associated with an increasingly large number of human disease states. Observations from in vivo models where mitochondrial function is altered suggest that adaptations to mitochondrial dysfunction may underpin disease pathology. We hypothesized that the severity of these maladaptations could be shaped by the plasticity of the system when mitochondrial dysfunction manifests. To investigate this, we have used inducible fly models of mitochondrial complex I (CI) dysfunction to reduce mitochondrial function at two stages of the fly lifecycle, from early development and adult eclosion.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Whole Body

SUBMITTER: Yizhou Yu  

LAB HEAD: Luis Miguel Martins

PROVIDER: PXD043791 | Pride | 2025-01-15

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
2626530893_YY_CxlRNAi_TMT11plex.msf Msf
2626530893_YY_CxlRNAi_TMT1_F01.raw Raw
2626530893_YY_CxlRNAi_TMT1_F02.raw Raw
2626530893_YY_CxlRNAi_TMT1_F03.raw Raw
2626530893_YY_CxlRNAi_TMT1_F04.raw Raw
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