Ontology highlight
ABSTRACT:
SUBMITTER: Smider BA
PROVIDER: S-EPMC7265228 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Smider Brevin A BA Smider Vaughn V VV
BMC immunology 20200602 1
<h4>Background</h4>Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single "ultralong" DH, IGHD8-2, encoding over 50 amino acids. Many bovine IGHD regions have sequence similarity but have several nucleotide repeating units that diversify their lengths. Genomically, most DH regions exist in three clusters that appear to have formed from DNA duplication events. Howeve ...[more]