Fam20C regulates protein secretion by Cab45 phosphorylation.
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ABSTRACT:
SUBMITTER: Hecht TK
PROVIDER: S-EPMC7265331 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Fam20C regulates protein secretion by Cab45 phosphorylation.
Hecht Tobias Karl-Heinz TK Blank Birgit B Steger Martin M Lopez Victor V Beck Gisela G Ramazanov Bulat B Mann Matthias M Tagliabracci Vincent V von Blume Julia J
The Journal of cell biology 20200601 6
The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into TGN-derived vesicles, which goes along with an increased export of LyzC, a Cab45 cl ...[more]
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