ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk ?-Valerobetaine.
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ABSTRACT:
SUBMITTER: D'Onofrio N
PROVIDER: S-EPMC7265370 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
ROS-Mediated Apoptotic Cell Death of Human Colon Cancer LoVo Cells by Milk δ-Valerobetaine.
D'Onofrio Nunzia N Cacciola Nunzio Antonio NA Martino Elisa E Borrelli Francesca F Fiorino Ferdinando F Lombardi Assunta A Neglia Gianluca G Balestrieri Maria Luisa ML Campanile Giuseppe G
Scientific reports 20200602 1
δ-Valerobetaine (δVB) is a constitutive milk metabolite with antioxidant and anti-inflammatory activities. Here, we tested the antineoplastic properties of milk δVB on human colorectal cancer cells. CCD 841 CoN (non-tumorigenic), HT-29 (p53 mutant adenocarcinoma) and LoVo (APC/RAS mutant adenocarcinoma) cells were exposed to 3 kDa milk extract, δVB (2 mM) or milk+δVB up to 72 h. Results showed a time- and dose-dependent capability of δVB to inhibit cancer cell viability, with higher potency in L ...[more]
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