Ontology highlight
ABSTRACT:
SUBMITTER: de Camargo LCB
PROVIDER: S-EPMC7265394 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
de Camargo Lívia Cardoso Bueno LCB Guaddachi Frédéric F Bergerat David D Ourari Nadia N Coillard Lucie L Parietti Veronique V Le Bras Morgane M Lehmann-Che Jacqueline J Jauliac Sébastien S
Scientific reports 20200602 1
Metastases are the main cause of cancer-induced deaths worldwide. To block tissue invasion, development of extracellular vesicles (EVs) as therapeutic carriers, appears as an exciting challenge. To this aim, we took advantage of the anti-invasive function of NFAT3 transcription factor we identified previously in breast cancer and addressed the opportunity to transfer this inhibitory function by EVs. We show here that EVs produced by poorly invasive NFAT3-expressing breast cancer cell lines are c ...[more]