Ontology highlight
ABSTRACT:
SUBMITTER: Yang LP
PROVIDER: S-EPMC7265396 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yang Liu-Pan LP Zhang Li L Quan Mao M Ward Jas S JS Ma Yan-Long YL Zhou Hang H Rissanen Kari K Jiang Wei W
Nature communications 20200602 1
Induced fit and conformational selection are two dominant binding mechanisms in biology. Although induced fit has been widely accepted by supramolecular chemists, conformational selection is rarely studied with synthetic systems. In the present research, we report a macrocyclic host whose binding mechanism is unambiguously assigned to conformational selection. The kinetic and thermodynamic aspects of this system are studied in great detail. It reveals that the kinetic equation commonly used for ...[more]