Ontology highlight
ABSTRACT:
SUBMITTER: Moal IH
PROVIDER: S-EPMC3257286 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Moal Iain H IH Bates Paul A PA
PLoS computational biology 20120112 1
The prediction of protein-protein kinetic rate constants provides a fundamental test of our understanding of molecular recognition, and will play an important role in the modeling of complex biological systems. In this paper, a feature selection and regression algorithm is applied to mine a large set of molecular descriptors and construct simple models for association and dissociation rate constants using empirical data. Using separate test data for validation, the predicted rate constants can b ...[more]