Ontology highlight
ABSTRACT:
SUBMITTER: Yang M
PROVIDER: S-EPMC7265486 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
NPJ systems biology and applications 20200602 1
Drug combinations can expand therapeutic options and address cancer's resistance. However, the combinatorial space is enormous precluding its systematic exploration. Therefore, synergy prediction strategies are essential. We here present an approach to prioritise drug combinations in high-throughput screens and to stratify synergistic responses. At the core of our approach is the observation that the likelihood of synergy increases when targeting proteins with either strong functional similarity ...[more]