Ontology highlight
ABSTRACT:
SUBMITTER: Vilar S
PROVIDER: S-EPMC4422192 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Vilar Santiago S Uriarte Eugenio E Santana Lourdes L Lorberbaum Tal T Hripcsak George G Friedman Carol C Tatonetti Nicholas P NP
Nature protocols 20140814 9
Drug-drug interactions (DDIs) are a major cause of adverse drug effects and a public health concern, as they increase hospital care expenses and reduce patients' quality of life. DDI detection is, therefore, an important objective in patient safety, one whose pursuit affects drug development and pharmacovigilance. In this article, we describe a protocol applicable on a large scale to predict novel DDIs based on similarity of drug interaction candidates to drugs involved in established DDIs. The ...[more]