Meat intake, meat cooking methods, and meat-derived mutagen exposure and risk of sessile serrated lesions.

ABSTRACT:

Background

Red and processed meat, recognized carcinogens, are risk factors for colorectal neoplasia, including polyps, the precursor for colorectal cancer. The mechanism is unclear. One possible explanation is the mutagenic activity of these foods, perhaps due to generation during cooking [e.g., heterocyclic amine (HCA) intake]. Few studies have evaluated meat intake and sessile serrated lesion (SSL) risk, a recently recognized precursor, and no study has evaluated meat cooking methods and meat-derived mutagens with SSL risk.

Objective

We evaluated intakes of meat, meat cooking methods, and inferred meat mutagens with SSL risk and in comparison to risk of other polyps.

Methods

Meat, well-done meat, and inferred meat mutagen intakes were evaluated. Polytomous logistic

SUBMITTER: Mosley D 

PROVIDER: S-EPMC7266682 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature