A Comparison of Intrathecal and Intravenous Morphine for Analgesia After Hepatectomy: A Randomized Controlled Trial.

ABSTRACT:

Background

Effective analgesia is essential for patient recovery after liver resection. This study aimed to evaluate the effects of the addition of preoperative intrathecal morphine to multimodal intravenous analgesia in patients undergoing liver resection.

Methods

In this single-blind randomized controlled trial, patients undergoing liver resection were randomly assigned to the patient-controlled analgesia with (ITM-IV) or without (IV) preoperative intrathecal morphine groups. All patients received acetaminophen and dexketoprofen. The primary outcome was pain severity at rest over three postoperative days, assessed using the numerical rating scale (NRS).

Results

The study included 36 patients (18 in each group). The mean maximum daily NRS scores over the first three

SUBMITTER: Niewinski G 

PROVIDER: S-EPMC7266793 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature